| Dr. Frasier Crane | |
Kelsey Grammer | Dr. Niles Crane | |
David Hyde Pierce |
| Martin Crane | |
John Mahoney | Daphne Moon | |
Jane Leeves |
| Roz Doyle | |
Peri Gilpin | Eddie | |
Moose |
| Lilith |  |
Bebe Neuwirth | Frederick | ||
| Maris |  |
----- | Cafe Nervosa Waitress | Luck Hari | |
| Bob "Bulldog" Briscoe |  |
Dan Butler | Gil Chesterton |  |
Edward Hibbert |
| Mel (ep. 152+) |
 |
Jane Adams | Donny Douglas (ep. 135+) |
Saul Rubinek | |
| Bebe Glaser (ep 9+) |
Harriet Sansom Harris | Kenny (ep. 120+) |
Tom McGowan | ||
| Noel Shempsky |  |
Patrick Kerr | Kate Costas (ep. 49 - 58) |
Mercedes Ruehl | |
| Sherry Dempsey (ep. 81 - 106) |
 |
Marsha Mason |
Maureen Cutler |
Jane Kaczmarek |
| Celebrity | Episode: | Called in as: | Problem | |
| Brooke Adams | 53 | Marylin | Lived in Wisconsin near Roz's cousin Billy Rayburn. | |
| Marv Albert | 74 | Jerry | ||
| Joan Allen | 65 | Lydia | Was receiving obscene phone calls. Was afraid to answer her own phone. | |
| Gillian Anderson | 140 | Jenny | A flight attendant who lives with her boyfriend and has great sex, but he avoids the subject of marriage. Dr. Nora calls her a whore. | |
| Kevin Bacon | 33 | Vic | Says he is having trouble with women. He is turned over to Roz where she recognizes him as "I left my wallet at home so could you pick up the check, babe?" | |
| Billy Barty | 65 | Chris | Snuck into his neighbor's backyard and shovelled shrimp into the air conditioner. | |
| David Benoit | 91 | Doug | ||
| Halle Berry | 111 | Betsy | Her husband wanted to take her on a cruise. Details of her recurring dream about water gushing into her cabin sent Roz rushing into the bathroom. | |
| Matthew Broderick | 49 | Mark | Liked to watch himself on the video camera at the mini-mart. | |
| Mel Brooks | 12 | Tom | Traumatized by the Christmas he found a dead puppy from Santa. | |
| Blair Brown | 50 | Jill | A girl on the other side of a glass had an important message for her, but she was unable to recieve it. | |
| Cyd Charisse | 55 | Called in to the radio show when Frasier was filling in for the Happy Chef, saying he was out of cinnamon. | ||
| Jill Clayburgh | 113 | Marie | She was having a hard time getting out of bed and when she did she was irritable for hours. Frasier suggested therapy, but Marie agreed with Dr. Clint Webber's opinion that she was hypoglycemic. | |
| Rosemary Clooney | 12 | Gladys | Fallen so many times they couldn't fit anymore pins in her hip. | |
| Betty Comden | 34 | Linda | She and her husband are lost, but he refuses to ask for directions. | |
| Bob Costas | 74 | Jake | Called for Bulldog, got Frasier instead and asked him a complicated basketball question. | |
| Cindy Crawford | 99 | Dorothy | Roz's manicurist. Dorothy got on air by mistake when Roz got confused as to which caller was on the line. | |
| Billy Crystal | 52 | Jack | A Bulldog fan who enjoyed the way the sports jock makes fun of Frasier. | |
| Kieran Culkin | 75 | Jimmy | Fourteen-year-old who thinks his parents are just like, "I dunno, really stupid." | |
| Macaulay Culkin | 35 | Elliott | After Frasier told him not to waste his time, Macaulay then explains his complaint is that people don't take him seriously because he has a young sounding voice. Frasier apologises. Macauly then gloats "Hah, gotcha doofus." | |
| John Cusack | 80 | Greg | First-year psychology student who was manifesting symptoms he was studying. | |
| Beverly D'Angelo | Audrey | Doesn't understand why she should fix the dress she ripped. Frasier: "Euripides, Eumenides." | ||
| Jeff Daniels | 5 | Doug | Concerned that his mother doesn't do anything and hangs around the house all day. | |
| Sandra Dee | 30 | Connie | Found Seattle a depressing place. | |
| Laura Dern | 54 | June | Likes to listen in on stranger's conversations in restaurants. | |
| Phil Donahue | 132 | Larry | Sophie wants some of her girlfriends to come over on Super Bowl Sunday. Larry refuses unless Frasier can answer a football question. | |
| David Duchovny | 70 | Tom | Has sex with his girlfriend every moning and night and three times a day on weekends, but is not sure they have anything in common. | |
| Patty Duke | 84 | Alice | Depressed woman to whom Frasier related the story of Eddie's depression and treatment. | |
| Dominick Dunne | 12 | Jeff | Watching The Sound of Music was his cures for the holiday blues. | |
| Griffin Dunne | 1 | Russell | Depressed because he felt that his life was going nowhere. | |
| Christopher Durang | 75 | Rudy | Man who cries when he watches sad movies. | |
| Shelley Duvall | 48 | Caroline | ||
| Julius Erving | 74 | Mike | Called for Bulldog, got Frasier instead and asked him what he thought of the damn Yankees then scoffed at Frasier's answers. | |
| Gloria Estefan | 160 | Maria | ||
| Carrie Fisher | 49 | Phyllis | A late-night caller in the episode where Kate banishes Frasier and Roz to the late shift. She complained of insomnia at a time when Frasier had fallen asleep on the radio console. "If I don't get some sleep soon, I'll go crazy," she said. Frasier missed that thought, and wakes up suddenly. His counsel: "Things look better in the light of day. My advice is to sleep on it." | |
| Jodie Foster | 61 | Marlene | Said that if she and her husband didn't have sex within the next two days, she would go to a department store and pick up a stranger. | |
| Art Garfunkel | 32 | Chester | His wife feels as if he's wasting his life, marking time. Frasier asks him to call tomorrow and he says he will hang on the line until tomorrow ... he has nothing pressing to do. | |
| Teri Garr | 49 | Nancy | Told Frasier she was wearing nothing. | |
| Eydie Gorme | 23 | Lois | (with Steve Lawrence) They couldn't say "I love you" to each other. | |
| Adolph Green | 34 | Walter | She and her husband are lost, but he refuses to ask for directions. | |
| Linda Hamiltion | 1 | Clare | Broke up with her boyfriend and couldn't get over it. | |
| Ed Harris | 52 | Rob | Called to praise Bulldog. Bulldog called him a suck up, told him to shut up and soon after cut him off. | |
| Patricia Hearst | 23 | Janice | Couldn't break through a barrier with her in-laws. | |
| Tommy Hilfiger | 23 | Robert | ||
| Ron Howard | 131 | Stephen | Hears people talking to him through his radio. | |
| Tom Hulce | 49 | Keith | A cop on his love for doughnuts. | |
| Eric Idle | 65 | Chuck | Put a hundred scorpions into a FedEx package. | |
| Judith Ivey | 4 | Lorraine | ||
| Bruno Kirby | 7 | Marco | ||
| Robert Klein | 6 | Gary | Sought marital advice. She wanted to go to Italy and he wanted to buy a sump pump. | |
| Marsha Kramer | 65 | Anne | ||
| Christine Lahti | 22 | Laura | Lost all her hair from a bad perm. | |
| Piper Laurie | 13 | Marianne | ||
| Steve Lawrence | 23 | Howard | (with Eddie Gorme) They couldn't say "I love you" to each other. | |
| Timothy Leary | 16 | Hank | ||
| Jay Leno | 10 | Don | Complained that he couldn't lose weight, calling from the drive-in window at a fast-food restaurant. | |
| Ray Liotta | 57 | Bob | Called from the airport at Christmas time. Wasn't sure whether to go home and see his parents or to go to Maui instead. | |
| John Lithgow | 43 | Madman Martinez | Calls up in disguise of having a problem, but really only plugs his car dealership. | |
| Patti LuPone | 3 | Pam | Had a problem with her in-laws. They dropped over without calling. | |
| Yo-Yo Ma | 140 | Tom | Having a problem with a coworker and wants to know what he can do about it. | |
| Willian H. Macy | 131 | Ralph | Frasier changed Ralph's tire. Ralph calls to say he's going to sue Frasier for scratching the car with his cufflinks. | |
| Amy Madigan | 28 | Maggie | She went out with a guy twice and he sent her roses everyday. She listened to Roz and dumped him. | |
| Henry Mancini | 13 | Al | He hated his voice. | |
| Joe Mantegna | 4 | Derek Mann | Columnist who hated Frasier and challenged him to a fist fight. | |
| Mary Elizabeth Mastrantonio | 51 | Eileen | The woman who fantasized about Frasier while making love to her husband. | |
| Armistead Maupin | Gerard | Wanted to be friends with Frasier and offered to comb his hair. | ||
| Paul Mazursky | 56 | Vinne | A womanizer who lost his pinkie ring, but didn't know where. Was hoping to use Frasier's show to find it. | |
| Malcolm McDowell | 19 | Dr. Bruga | ||
| John McEnroe | 120 | Patrick | He wasn't sure if his wife was having an affair. Frasier suggested Patrick make her a romantic dinner that evening, but she was working late on her boss' boat again. | |
| Reba McEntire | 20 | Rachel | Her husband insisted on keeping an urn of his late wife's ashes on their bedroom dresser. | |
| Isaac Mizrahi | 160 | Gabe | ||
| Mary Tyler Moore | 23 | Marjorie | Couldn't confront her boss. | |
| Bess Myerson | 109 | Mary | Spoke to Roz and said she was indecisive. Roz hung up on her. | |
| Jerry Orbach | 65 | Mitch | Had trouble with his neighbor and his leaf blower. | |
| Jane Pauley | 65 | Anne | She set someone's lawn on fire for not curbing their dog. | |
| Rosie Perez | 36 | Francesca | ||
| Sydney Pollack | 31 | Holden Thorpe | A politician running for office who called in to say that America would be a much better place the day more people like Frasier were off the air and more pols like the caller were elected. | |
| Faith Prince | 63 | Brandy | Called and said her would-be hubby wasn't there for her, wouldn't let her work and was too quick in bed. I recalling their most recent post-sex conversation: "I said to him last night 'What the hell was that? I've been vaccinated slower.'" | |
| Bonnie Raitt | 140 | Denise | Nothing she ever does is good enough for her mother. Frasier suggests counseling. Dr. Nora says to cut her out of her life like a tumor. | |
| Christopher Reeve | 2 | Leonard | An agoraphobic who was afraid of large open spaces. | |
| Carl Reiner | 9 | Roger | Couldn't decide what to name his new cabin cruiser. | |
| Rob Reiner | 109 | Bill | Called with a bed-wetting problem. Roz juiced up his problem so he became a bed-wetting adulterer. | |
| Eric Roberts | 87 | Chet | Man who had called once before about low self- esteem. Now says people tell him he's arrogant and tells Frasier to get lost when he suggests that he may have taken his advice too far. | |
| Carly Simon | 36 | Marie | There's a forty-year-old man she would like to go out with, but he has never been married. She's calling from a pay phone. | |
| Gary Sinise | 42 | Sid | He is reading what he says to Frasier. He writes everything down before having a conversation with someone. | |
| James Spader | 25 | Steven | He and his wife are having a baby. Is it OK to let your kid climb into bed with you? | |
| Mary Steenburgen | 37 | Marjorie | ||
| Ben Stiller | 12 | Barry | On Christmas, he couldn't stop crying to discuss his problem. | |
| Eric Stoltz | 12 | Don | ||
| Marlo Thomas | 132 | Sophie | Sophie wants some of her girlfriends to come over on Super Bowl Sunday. Larry refuses unless Frasier can answer a football question. | |
| Lily Tomlin | 26 | Rita | Thinks she is losing her mind by raising four kids all by herself. Not enough time in the day for everything. She feels as if she is going to snap. | |
| Randy Travis | 63 | "Man" | Would binge then starve so he could fit into fancy evening gowns. | |
| Garry Trudeau | 23 | Louis | The KACL restaurant critic Gil Chesterton got his reservations at Maxamillians after he forgot it was his anniversary. | |
| Eddie Van Halen | 7 | Hank | Had a problem with his neighbor. Hank never told Frasier what his problem was, because he kept trying to hear himself over the radio. | |
| John Waters | 109 | Roger | ||
| Wendy Wasserstein | 77 | Linda | ||
| JoBeth Williams | 8 | Danielle | Before appearing as Madeline the sportswear entrepeneur who goes to Bora Bora with Frasier, the actress lent her voice as a Frenchwoman who was having problems with her "Mutheot". | |
| Katarina Witt | 65 | Brenda | She was having problems with her sister. Before she could go into detail she got another call and put Frasier on hold. | |
| Elijah Wood | 13 | Ethan | The kids at school beat him up because he was smart. He found Frasier's advice patronizing, simplistic and uninspired. | |
| Alfre Woodard | 30 | Edna | A depressed receptionist at a pest-control company. | |
| Steve Young | 23 | Blake | ||
| Pia Zadora | 140 | Jill | Found out her husband is gay and wants a divorce. Dr. Nora says to make it work. |